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 ORIGINAL ARTICLE
Year : 2006  |  Volume : 10  |  Issue : 1  |  Page : 24-27

Altered pituitary hormone secretion in male rats exposed to bisphenol A


1 Department of Anatomy, School of Medicine, Gorgan University of Medical Sciences, Department of Anatomy, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran
2 Department of Anatomy, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran
3 Department of Physiology, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran
4 Department of Pathology, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran
5 Department of Chemistry, School of Sciences, Razi University, Kerman Shah, Iran
6 Department of Biophysics, School of Medicine, Kerman Shah University of Medical Science, Kerman Shah, Iran

Correspondence Address:
A M Gharravi
Department of Anatomy, Gorgan University of Medical Sciences, Gorgan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5278.22891

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Bisphenol A (BPA) is a xenobiotic estrogenic compound. This compound has been suspected to have estrogenic effects on reproductive system of males and females. In this present study we investigated possible low-dose effects of BPA on Luteinizing Hormone in rats. Male Wistar rats (12-13 weeks old) were administrated a daily intra peritoneal 10 g/kgbw/day, 50 g/kgbw/day, 100 g/kgbw/day dose of BPA for 6, 6, and 12 days, and one day after last injection, serum level of Luteinizing Hormone was examined by ELISA method. All data were expressed as means SE. Two-way ANOVA was performed. Analysis of data showed that in all dose groups, plasma level of Luteinizing Hormone significantly decreased compared to control group. The present study showed that BPA at low doses affects Luteinizing Hormone, one of main hormones in spermatogenesis in the adult Wistar rats, and subsequently alters the steroidgenesis in testicular Leydig cells.






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