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 ORIGINAL ARTICLE
Year : 2009  |  Volume : 13  |  Issue : 1  |  Page : 23-27

Assessment of erythrocyte acetylcholine esterase activities in painters


1 Department of Biochemistry, C. S. M. Medical University, Lucknow, India
2 Department of Biochemistry, J. N. Medical University, Aligarh Muslim University, Aligarh, India
3 Emeritus Scientist, Indian Institute of Toxicology and Research, Lucknow, India
4 Biometry Division, Central Drug Research Institute, Lucknow, India

Correspondence Address:
Abbas Ali Mahdi
Department of Biochemistry, C. S. M. Medical University, Lucknow, Uttar Pradesh - 226 003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5278.50720

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Thirty-five male painters in the age group of 20-50 years occupationally engaged in domestic and commercial painting for 5-12 years having blood lead levels (BLL) ≤40 g/dl were subjected to the determination of acetyl choline esterase (AChE) levels both in plasma and red blood cell (RBC) lysate. BLL were determined using a graphite furnace atomic absorption spectrometer. The results showed that BLL were 7.7 times higher in the painters as compared with that of the control group. Significant decreases in RBC and plasma AChE were observed in the exposed group in comparison with controls. RBC and plasma AChE showed a decrease of 18.4% and 18%, respectively, in the exposed group. The findings also indicated a significant negative correlation of both RBC and plasma AChE activities with BLL. The marked reduction observed in both RBC and plasma AChE activity may account for disruption of cholinergic function and result in neurotoxicity among the painters.






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