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 ORIGINAL ARTICLE
Year : 2009  |  Volume : 13  |  Issue : 2  |  Page : 84-87

Rapid method for the determination of some organophosphorus insecticides in a small amount of serum in emergency and occupational toxicology cases


Department of Forensic Medicine & Toxicology, All India Institute of Medical Sciences, New Delhi - 110029, India

Correspondence Address:
Bhoopendra Singh
Department of Forensic Medicine & Toxicology, Rural Medical College, Pravara Institute of Medical Sciences (Deemed University), Loni - 413736, Ahmednagar, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5278.55125

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A simple and rapid method is described for the estimation of some organophosphorus insecticides in the serum of occupationally exposed persons. The compounds are extracted with a mixture of acetone and diethyl ether (1:1 v/v) in acidic medium and the extraction residue is analyzed by gas chromatography with nitrogen phosphorus detection method. Linearity was acceptable over concentrations from 0.25 to 4.0 g/mL. The method percentile recovery for the six different organophosphorus insecticides was 86.3% for phorate, 78.3% for dimethoate, 82.3% for malathion, 79.4% for chlorpyrifos, 80.2% for diazinon, and 68.5% for ethion at the g/mL level. Serum samples of nine workers who had been occupationally exposed to malathion in an insecticide manufacturing factory, were analyzed and malathion was found at low levels in all the samples.






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