Indian J Occup Environ Med Close
 

Figure 3: Repair of oxidative DNA damage caused by pesticides. Oxidative damage is repaired by a set of base excision genes, i.e., hOGG1, APE1, and XRCC1. (a) First the damage base is recognized by OGG1 gene which removes the oxidative base creating an AP site. APE1 repairs the AP site. XRCC1 recruits β-DNA Polymerase to synthesize new base, and the nick is sealed by DNA ligase. (b) However, mutation in these genes modulates the repair capacity. Polymorphic genes alter gene function by producing alternate enzyme leading to incorporation of mutated base which can results in cancer or apoptosis etc

Figure 3: Repair of oxidative DNA damage caused by pesticides. Oxidative damage is repaired by a set of base excision genes, i.e., <i>hOGG1, APE1</i>, and <i>XRCC1</i>. (a) First the damage base is recognized by <i>OGG1</i> gene which removes the oxidative base creating an AP site. <i>APE1</i> repairs the AP site. <i>XRCC1</i> recruits β-DNA Polymerase to synthesize new base, and the nick is sealed by DNA ligase. (b) However, mutation in these genes modulates the repair capacity. Polymorphic genes alter gene function by producing alternate enzyme leading to incorporation of mutated base which can results in cancer or apoptosis etc