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Year : 2008  |  Volume : 12  |  Issue : 3  |  Page : 107-111

Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases


National Institute of Miner's Health, JNARDDC Campus, Nagpur, India

Correspondence Address:
Shubhangi K Pingle
Research Officer, National Institute of Miners' Health, JNARDDC Campus, Wadi, Nagpur - 440 023
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5278.44690

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Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with γ-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.






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