Indian Journal of Occupational and Environmental Medicine   Official publication of Indian Association of  0ccupational  Health  
 Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Users Online:845

  IAOH | Subscription | e-Alerts | Feedback | Login 

Home About us Current Issue Archives Search Instructions
   Next article
   Previous article
   Table of Contents

   Similar in PUBMED
     Search Pubmed for
     Search in Google Scholar for
   Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded123    
    Comments [Add]    
    Cited by others 23    

Recommend this journal


Year : 2018  |  Volume : 22  |  Issue : 2  |  Page : 74-81

Occupational pesticide exposure, impaired DNA repair, and diseases

Department of Biotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India

Correspondence Address:
Dr. Rupinder Kaur
Department of Biotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib - 140 406, Punjab
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijoem.IJOEM_45_18

Rights and Permissions

Pesticides are a mixture of chemical substances used to kill pests. Apart from their toxicity to pests, thy affect nontarget organisms. They also generate free radicals producing reactive oxygen species (ROS) which can disturb cellular pathways by inhibiting various enzymes or receptors. Pesticides also induce oxidative DNA damage, DNA adducts, and single or double strand DNA breaks. Various mechanisms of DNA repair deal with such damages and help to maintain cell integrity. Alteration in DNA repair genes modulates the individual's susceptibility towards DNA repair and various diseases. Biological monitoring provides a useful tool for the estimation of genetic risk in populations exposed to pesticides. Large numbers of evidences show that occupational exposure to pesticides in agricultural workers has been associated with an increased incidence of various diseases such as cancer, Parkinson's disease, Alzheimer's disease, reproductive disorders, and birth defects. In this review, we have discussed occupational pesticide exposure, various mechanisms of DNA damage caused by pesticides, DNA repair mechanisms, biomonitoring tools, and various diseases caused by pesticide exposure.


Print this article     Email this article