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Year : 2022  |  Volume : 26  |  Issue : 4  |  Page : 285-288

Erasmus syndrome: A case series of rare co-occurrence of silicosis and systemic sclerosis

Department of Respiratory Medicine, Institute of Respiratory Diseases, SMS Medical College, Jaipur, Rajasthan, India

Correspondence Address:
Dr. Manisha Jain
E-182, Shiv Park, Ambabari, Jaipur, Rajasthan - 302 039
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijoem.ijoem_362_21

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Erasmus syndrome is the association of silica exposure and subsequent development of systemic sclerosis. Here we discuss five cases that presented with progressive shortness of breath, arthralgia, skin tightening, and Raynaud's phenomenon. History of exposure to silica dust was present in all cases, and further serological (Anti-Scl-70 antibody positive), radiological, and histopathological (skin biopsy) investigations confirmed the diagnosis of systemic sclerosis. Hence the diagnosis of Erasmus syndrome was made. Therefore, careful screening should be done in patients of silicosis with systemic symptoms to rule out any associated connective tissue disorder. Timely diagnosis and early intervention can prevent the patients from developing life-threatening complications and improved quality of life.


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